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        "full_name": "Dave Messina",
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        "body": "**tl;dr:** Signatur Biosciences is a B2B molecular diagnostics design company. Our technology expands PCR testing to a whole new range of conditions. We design smart PCR kits that can detect complex diseases as easily as a COVID test, using standard qPCR machines. Our tests seamlessly integrate into existing clinical workflows and ubiquitous laboratory instruments, empowering us to become _the_ enabling technology platform for a $20B industry.\n\n👋 Hey everyone! We’re Celestin and John. We are determined to transform the state of medical diagnostics. We set out to find a solution that delivers state-of-the art diagnosis on ubiquitous instrumentation to put cutting-edge healthcare within the reach of everyone, everywhere.\n\n### **The Problem.**\n\nRight now, PCR testing is limited to simple diseases. Covid is a good example. You take a sample from a patient and look for one biomarker. If the biomarker is there, the patient has the disease; no biomarker, no disease. Simple.\n\nBut most conditions aren't that simple. There’s a $20B industry using _patterns_ of multiple biomarkers that diagnose complex diseases, but to deploy their tests they’re relying on legacy technologies that are too slow and expensive to really help people, limiting their market reach.\n\n### **🧬 Signatur Biosciences’s solution.**\n\nOur platform expands PCR testing to a whole new range of conditions, beyond just infectious disease to include everything from chronic diseases, treatment selection, and disease monitoring.\n\nWe have re-engineered the molecular architecture of the polymerase chain reaction, empowering it to process the information from multiple biomarkers simultaneously. We combine the power of gene signature diagnosis with the **_ease and familiarity of a single PCR reaction._**\n\nEvery biomedical lab in the planet is equipped with PCR machines. This was true before the pandemic. But as a response to the pandemic, the PCR testing capacity in the US has increased by 5500% (3000% in the UK). We are giving those machines something new to do.\n\n### **🚀 How can Signatur Biosciences help me?**\n\nWe are partnering with companies to design our platform around their biomarker panels, offering broader market reach bringing such tests to more patients.\n\nIn parallel, we are building our own assay portfolio. We are developing our own internal pipeline of tests to tackle diseases that can only be interrogated by our technology.\n\n### **How you can help.**\n\nWe are looking for introductions to companies in the molecular diagnostics space. This could be companies developing portable hardware. Specifically developing genomic testing, or assays based on gene expression analysis.",
        "url": "https://www.ycombinator.com/launches/Gl3-signatur-biosciences-diagnoses-anything-with-a-simple-pcr-test",
        "votes": 20,
        "created_at": "2022-07-07T15:51:11.366Z"
      }
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  {
    "id": 27828,
    "name": "Scanbase",
    "slug": "scanbase",
    "former_names": [
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    "small_logo_thumb_url": "https://bookface-images.s3.amazonaws.com/small_logos/c9177f461ffabba1796fab772ec9f376ad91bf4e.png",
    "website": "https://www.scanbase.com",
    "all_locations": "Los Angeles, CA, USA",
    "long_description": "Scanbase makes it easy for medical companies to convert photos of rapid diagnostic tests into results. We do this by providing a simple API that any medical company can access.\r\n",
    "one_liner": "The API for Diagnostic Test Analysis (COVID-19, FLU, RSV, STD,…",
    "team_size": 10,
    "industry": "Healthcare",
    "subindustry": "Healthcare -> Diagnostics",
    "launched_at": 1670991822,
    "tags": [
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    "isHiring": false,
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    "batch": "Winter 2023",
    "status": "Active",
    "industries": [
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    "regions": [
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      "America / Canada"
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    "stage": "Early",
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    "url": "https://www.ycombinator.com/companies/scanbase",
    "api": "https://devasheeshg.github.io/yc-api/batches/winter-2023/scanbase.json",
    "year_founded": 2022,
    "city": "Los Angeles",
    "country": "US",
    "linkedin_url": "https://www.linkedin.com/company/scanbases/",
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    "primary_partner": {
      "name": "Tom Blomfield",
      "url": "https://www.ycombinator.com/people/tom-blomfield"
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    "founders": [
      {
        "user_id": 1162081,
        "full_name": "Jeffrey Lange",
        "title": "Founder",
        "founder_bio": "Jeffrey is currently the CEO of Scanbase, a seed stage diagnostic scanning API used by at-home test manufacturers. He is a graduate of the Rhode Island School of Design.",
        "is_active": true,
        "linkedin_url": "https://www.linkedin.com/in/langejeff/",
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      {
        "user_id": 1150701,
        "full_name": "Steve Roger",
        "title": "Founder",
        "founder_bio": "CTO of Scanbase with 10+ years building enterprise level APIs, and products. Steve holds a degree in CS from UC Berkeley. Ex-LinkedIn.",
        "is_active": true,
        "linkedin_url": "https://www.linkedin.com/in/steveroger/",
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    ],
    "jobs": [],
    "news": [
      {
        "title": "Y Combinator’s Most Recent Winter 2023 Batch Shows A Shift To AI, DevTools And B2B ",
        "url": "https://news.crunchbase.com/venture/y-combinator-winter-2023-shift-ai-devtools-b2b/",
        "date": "Apr 12, 2023"
      },
      {
        "title": "Our favorite startups from YC’s Winter 2023 Demo Day — Part 2 | TechCrunch",
        "url": "https://techcrunch.com/2023/04/06/y-combinator-demo-day-2023-favorites-part-two/",
        "date": "Apr 06, 2023"
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    "launches": [
      {
        "id": 68414,
        "title": "Scanbase API - Converting Diagnostic Tests to Results, Next Steps, and Treatment",
        "tagline": "COVID-19, Flu, Pregnancy, RSV, STD/STI, HIV, CKD, UTI, and many more...",
        "body": "![uploaded image](/media/?type=post&id=68414&key=user_uploads/1162081/724cd23c-f4df-4100-954e-379c4f248340)\n\n![uploaded image](/media/?type=post&id=68414&key=user_uploads/1162081/047c2be5-f90d-4a0b-acc6-693a32527879)\n\n![uploaded image](/media/?type=post&id=68414&key=user_uploads/1162081/d6a6fc05-b35f-4382-8d04-5a1c04c5bec0)\n\n[Book a demo](https://www.scanbase.com/schedule-a-demo) and learn how Scanbase can enhance your diagnostic program.\n\n![uploaded image](/media/?type=post&id=68414&key=user_uploads/1162081/9151ad3b-aee8-469f-85a8-865f70e98b45)\n\nWatch a demo of a Scanbase’s algorithm interpreting a **low positive** test!\n\n![uploaded image](/media/?type=post&id=68414&key=user_uploads/1162081/bb4bb5c4-0806-4417-a3e9-a05347115195)\n\n![uploaded image](/media/?type=post&id=68414&key=user_uploads/1162081/c31413ed-9102-4eb6-acfd-f4016a843ab4)\n\n![uploaded image](/media/?type=post&id=68414&key=user_uploads/1162081/b9e1ac86-a480-48f7-9663-57c6dc724723)\n\nInterested in digitizing your diagnostic tests and don’t have an app? Reach out to us at [info@scanbase.com](mailto:info@scanbase.com) to learn how we’re helping diagnostics companies digitize from the ground up.\n\n![uploaded image](/media/?type=post&id=68414&key=user_uploads/1162081/4378e1d7-15cd-4dfa-88af-66f0c64babeb)\n\n![uploaded image](/media/?type=post&id=68414&key=user_uploads/1162081/821f585b-f832-4df7-8b91-21ca677a0d14)\n\nDon’t see the test you’re looking for? Let know at [info@scanbase.com](mailto:info@scanbase.com).\n\n![uploaded image](/media/?type=post&id=68414&key=user_uploads/1162081/2809d76e-b3e0-405f-925c-82af759f4115)\n\n[Book a demo](https://www.scanbase.com/schedule-a-demo) and learn how Scanbase can enhance your diagnostic program.\\\n\\\n**We believe that everyone deserves access to the best healthcare technology has to offer.** Founded in 2022 and based in San Francisco, California, Scanbase is an API that allows medical companies to enable smartphone-based computer vision quickly so anyone anywhere can analyze their at-home test results with confidence.\\\n\\\nIf you are interested in learning more or joining our team, shoot us an email at [info@scanbase.com](mailto:info@scanbase.com) and we’ll get back to you right away.",
        "url": "https://www.ycombinator.com/launches/HnS-scanbase-api-converting-diagnostic-tests-to-results-next-steps-and-treatment",
        "votes": 109,
        "created_at": "2023-01-13T09:08:29.284Z"
      }
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    "id": 28859,
    "name": "MICSI",
    "slug": "micsi",
    "former_names": [
      "MICSI (Microstructure Imaging, Inc)"
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    "website": "https://www.micsi.co/",
    "all_locations": "New York City, NY, USA",
    "long_description": "MICSI is introducing AI software that doubles resolution and halves scan time. This breakthrough enables imaging centers to significantly enhance their capacity and patient throughput, potentially saving countless lives and generating an additional $2 million of revenue per MRI scanner. Our initial offering serves as a stepping stone toward the company’s larger vision of transforming the MRI into a truly quantitative instrument that is capable of providing highly reproducible data for more accurate diagnoses and patient management. ",
    "one_liner": "Higher resolution MRI with faster scan times.",
    "team_size": 2,
    "industry": "Healthcare",
    "subindustry": "Healthcare -> Diagnostics",
    "launched_at": 1687381964,
    "tags": [
      "Computer Vision",
      "Medical Devices",
      "Healthcare"
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    "nonprofit": false,
    "batch": "Summer 2023",
    "status": "Active",
    "industries": [
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      "America / Canada"
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    "stage": "Early",
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    "url": "https://www.ycombinator.com/companies/micsi",
    "api": "https://devasheeshg.github.io/yc-api/batches/summer-2023/micsi.json",
    "year_founded": 2018,
    "city": "New York City",
    "country": "US",
    "linkedin_url": "https://www.linkedin.com/company/microstructure-imaging-inc/",
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      {
        "user_id": 1352304,
        "full_name": "Gregory Lemberskiy",
        "title": "Founder",
        "founder_bio": "Gregory Lemberskiy (CEO) co-founded MICSI with goal of bringing cutting edge image processing tools, that he encountered in the research setting into clinical practice. His PhD work (2019) focused on algorithm development for image enhancement and biophysical modeling of the MRI signal. His methods have been used to enable high-end quality on low field MRI systems through noise reduction (MICSI’s first product) and use MRI to characterize the physical properties of prostate glandular lumen.",
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      {
        "user_id": 1352419,
        "full_name": "Benjamin Ades-Aron",
        "title": "Founder",
        "founder_bio": "I got my PhD in electrical engineering in 2022 from NYU, where I specialized in developing machine learning based computer vision algorithms for the visualization of MRI data. I specialize in developing software to process and route diffusion and functional MRI data, with a goal of improving image signal, reducing noise, and producing clinically viable diagnostic imaging biomarkers.",
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      {
        "id": 96226,
        "title": "MICSI-PET: Anatomical Positron Emission Tomography",
        "tagline": "Making PET imaging fast, anatomical, and scalable for Alzheimer’s care.",
        "body": "TLDR; MICSI-PET makes PET imaging fast, anatomical, and scalable for Alzheimer’s care.\n\n![uploaded image](/media/?type=post&id=96226&key=user_uploads/1352304/a5488138-be4b-4093-86c1-1b2663488117)\n\n**Problem:** **PET is the bottleneck capping the entire Alzheimer’s market.**\n\n![uploaded image](/media/?type=post&id=96226&key=user_uploads/1352304/40ba7516-1b46-454a-9a26-98fb91fe3169)\n\nDisease modifying Alzheimer’s drugs like Leqembi and Kisunla are here, and they are projected to generate $5-8B/year by 2030. However, to get these drugs, patients need a positive amyloid PET scan.\n\nThis is an ambitious figure that is limited by the fact that there are only 2500 PET/CT scanners in the US, where the average age is 14 years old. PET scanners have a predictable 4-5% drop in sensitivity (or detected count rate) per year \\[Watanuki et al. Ann Nucl Med. 2010\\], suggesting a loss of half of the sensitivity since its initial install. Operationally, this sensitivity loss forces centers to lengthen acquisitions or increase dose just to preserve image quality, reducing throughput or margins right as amyloid PET demand is exploding. It’s also unrealistic to assume that the existing PET fleet is built for imaging Alzheimer’s at scale. PET systems are also heavily utilized for oncology, cardiology, infection, and presurgical planning, where 74% of all PET scans use FDG, a general purpose tracer for cellular metabolism. \n\n**Solution: Transform aging PET fleets into Anatomical PET with MICSI-PET.**\n\n![uploaded image](/media/?type=post&id=96226&key=user_uploads/1352304/be3b873c-3dd7-4326-8447-316161d179db)\n\nMICSI-PET is a turnkey upgrade that dramatically enhances PET image quality by using the MRI as an anatomical guide. This process does not require any additional imaging as all patients should have received an MRI prior to amyloid PET imaging. Operationally, this upgrade removes the primary barrier for scaling Alzheimer’s therapies by (1) enabling high-end PET imaging on low-end or aging PET scanners; (2) enabling shorter PET examinations leading to greater throughput; (3) minimizing ambiguity of positive/negative amyloid PET imaging by showing clearer boundaries between gray and white matter:\n\n![uploaded image](/media/?type=post&id=96226&key=user_uploads/1352304/90dd7722-405d-4a4f-967b-4ec6df183ff6)\n\n**Figure:** Coregistered conventional PET and MICSI-PET amyloid images across a range of amyloid burdens, highlighting differences in apparent cortical sparing: **left, amyloid-negative** with strong gray/white contrast; **right, amyloid-positive** with reduced gray/white contrast.\n\n**Addressing the Radiologist Workforce Crisis:** Scaling Alzheimer's care isn't just a hardware problem; it's a workforce problem. AD imaging is about to become a high-volume modality layered onto a nuclear medicine workforce where 54% of radiologists already report burnout.\n\nBeyond anatomical PET, MICSI-PET is designed to streamline diagnosis through automatic SUVR/Centiloid reporting with built-in QC.\n\n![uploaded image](/media/?type=post&id=96226&key=user_uploads/1352304/b48c9a16-d7b6-4fe9-bf74-509653e159dd)\n\nFast and anatomical PET is just the start. The same MR-guided upgrade would generalize across tracers, and eventually across doses, elevating the global standard of PET toward a new default: molecular imaging that’s both specific and anatomically precise. \n\nOur first product, MICSI-RMT, is already FDA-cleared and in the market. MICSI-PET is currently in clinical validation and we are preparing our FDA submission.\n\n**Ask:** We are expanding pre-FDA clearance pilot collaborations to validate MICSI-PET across sites and workflows, and we are closing a seed extension to support multi-center validation and early installs. If you lead a PET imaging program or invest in medical imaging and Alzheimer’s care, we would love to connect.  \n\n**Email Us:** \n\n[**Gregory.Lemberskiy@micsi.com**](mailto:Gregory.Lemberskiy@micsi.com)\n\n[**Benjamin.Adesaron@micsi.com**](mailto:Benjamin.Adesaron@micsi.com)",
        "url": "https://www.ycombinator.com/launches/P22-micsi-pet-anatomical-positron-emission-tomography",
        "votes": 16,
        "created_at": "2025-12-16T00:02:25.484Z"
      },
      {
        "id": 73719,
        "title": "MICSI (Microstructure Imaging)",
        "tagline": "Higher resolution MRI acquired faster",
        "body": "TLDR; MICSI is introducing an innovative image processing algorithm to decrease MRI scan time, increase image resolution, and unlock new diagnostic capabilities using Microstructure Imaging.\n\n![](https://lh4.googleusercontent.com/166C-4hbfRCmiC20D9EbOVhdubPqEE3tuTb-ZvNh8bnOXts8Rf9ZfhssNQ8ptJsGYAFqtkSt6w9Cu-aRvnBDBoKesDzc1ou7ddUVUZqTZ0knq8MmlZsbLWYY4rpGoFqUmrbmjEeSjfMx7KMKRdEngWA)\n\n**Problem: MRI Centers are overbooked.**\n\nIf you've ever had an MRI, you've probably waited weeks for an available slot and then spent a long time in the scanner. These long scan times inconvenience patients, create hospital backlogs, and delay appointments. Delays like these can critically impact conditions that require prompt diagnosis and intervention, inflate healthcare costs, increase patient anxiety, and potentially compromise treatment strategies. Why the wait? An MRI of the whole brain can be acquired in [**seconds**](https://mriquestions.com/echo-planar-imaging.html)!\n\n**Compromise: Why is your MRI an hour long?**\n\nMost of the scan time is spent on preserving signal-to-noise ratio (SNR) to produce images of the highest quality. These standard SNR preserving methods include:\n\n* Line-by-line acquisitions: These are fax-machine-like acquisitions that read the image one line at a time, where the time spent on each line is equivalent to the time that could have been spent acquiring the whole image.\n* Averaging: To boost SNR, images may be reacquired and averaged together. However, SNR improves slowly as a square root of scan time (ie 4 images are required to double the SNR).\n\nAn additional compromise is related to the spatial resolution, since MRI is acquired in 3D with “voxels”, doubling the resolution in each dimension from (2x2x2 mm3 to 1x1x1 mm3) would require the SNR to increase by **8x**, which even after 50 years of innovation, seems near impossible.\n\n![](https://lh4.googleusercontent.com/y1p1DzihqAvnmKvtoSJAbVSBrInECVUP2GvzVc5TFmLNqwTQ1hevnLgcPX7iplxNhKchrjAAQq8L8WlPbLNVWX31jAN-VIg6dSJ7Nzv-lKMUTvy8xsUIlzfFOZLlgSoGL0ZAC1lk8xqtYL2V4Q1caJk)\n\n**The MRI exam is full of compromise.**\n\n* Long scan times means fewer patients can be scanned by a given radiology center.\n* Lower resolution means a compromise in anatomical accuracy, where pathologies that could have otherwise been detected at an earlier stage would need to progress further to be MR visible.\n\nWe believe that the ultimate compromise is that MRI is not being used to its fullest potential for microstructure imaging, where MRI could be used to [**image cellular properties non-invasively**](https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/nbm.3998).\n\n**Solution: Boosting SNR over the MRI exam using MICSI-RMT.**\n\nOur patented approach (pending FDA510k clearance in Q4-2023) uses a self-supervised AI method to learn the noise properties of the MRI exam and remove noise uniformly across all images of the dataset. Our algorithm, MICSI-RMT, can be described as a smart averaging approach, whereby many images of the MRI exam are combined while preserving their unique image properties and discarding the noise. This boost in SNR would be approximately, sqrt(M/P), where M is the number of images included in the dataset, whereas P describes how different the images are (physical properties: proton density, T1, T2, diffusion, etc + artifacts: motion, errors, etc).\n\nMICSI-RMT is the commercial implementation of the MP-PCA algorithm that was developed by our research group led by Drs. Dmitry S. Novikov and Els Fieremans of NYU Radiology’s Center for Biomedical Imaging.\n\nMP-PCA is the most popular denoising approach in the MRI community:\n\n* The [**original paper**](https://pubmed.ncbi.nlm.nih.gov/27523449/) introducing the approach has achieved over 1300 citations since November 2016.\n* Denoising of [**task-based FMRI**](https://pubs.rsna.org/doi/full/10.1148/radiol.2020200822) for presurgical planning of Neurosurgery\n* Enabling low field [**0\\.55T prostate diffusion**](https://pubmed.ncbi.nlm.nih.gov/37222526/) MRI\n\nWith MICSI-RMT, MRI centers will not only be able to provide higher quality imaging but also drastically reduce the scan time (up to [50%](https://pubs.rsna.org/doi/full/10.1148/radiol.2020200822)). This improved efficiency allows centers to scan more patients per day, enhancing their operational capacity and throughput. Financially, this increase in capacity translates into a significant boost in revenue for every MRI center. By doubling the number of patients scanned daily, we estimate an additional $2 million in annual revenue per MRI scanner. Furthermore, the improved image quality and resolution could lead to more accurate diagnoses, early disease detection, and reducing overall healthcare costs in the long run.\n\n**Who we are - Greg and Ben**\n\n![](https://lh6.googleusercontent.com/F5FGyVn85R_Oxvkgw_uEOhvkKUEg_2VemnSso8p1nBfc7vgYVd1q1Vnt2BgIJrm2CRenojq9RkwoxbuP0lebYfKIcs6anX6wQEPQj0T-yaTJGLBOvqqzsw4JL4ftzrHLozX-QX592SesWUotkt92ZCw)\n\nWe are scientists and engineers who have spent the last decade developing machine learning software to both improve the quality diagnostic utility of MRI. [**Gregory Lemberskiy, PhD**](https://www.linkedin.com/in/gregory-lemberskiy/) is an [**experimental physicist**](https://scholar.google.com/citations?user=_TvugCIAAAAJ&hl=en). He discovered how to use MRI to measure the diameter of the [**prostate glandular lumen**](https://www.frontiersin.org/articles/10.3389/fphy.2018.00091/full), which may obviate the need for tissue biopsy to detect prostate cancer progression. [**Benjamin Ades-Aron, PhD**](https://www.linkedin.com/in/benjamin-aron-b0313349/) is an [**electrical engineer**](https://scholar.google.com/citations?user=xNhHFuAAAAAJ&hl=en) who developed and deployed the [**DESIGNER**](https://pubmed.ncbi.nlm.nih.gov/30077743/) open-source image processing pipeline, which is the global gold standard of diffusion MRI image processing. He has also developed a number of novel neural network architectures to aid in the denoising of compressed sensing MRI data, to facilitate brain mapping for functional neurosurgery of Epilepsy and brain tumor.\n\nTogether, the MICSI team owns over a dozen approved patents and has a clear vision for the future of MRI. The goal of MICSI is to use our patented denoising and parameter estimation technologies to make MRI quantitative and reproducible for the first time, creating a new category in diagnostic healthcare and improving patient satisfaction and outcomes.\n\n**Our Ask**\n\n* Do you know anyone in private practice, hospitals, or in large academic centers who may be interested in our approach? We want to talk to them.\n* Questions, comments, feedback? We want to hear from you!\n\n**Email us:**\n\n[**Gregory.Lemberskiy@micsi.com**](mailto:Gregory.Lemberskiy@micsi.co)\n\n[**Benjamin.adesaron@micsi.com**](mailto:Benjamin.adesaron@micsi.co)",
        "url": "https://www.ycombinator.com/launches/JB1-micsi-microstructure-imaging",
        "votes": 23,
        "created_at": "2023-08-02T17:20:50.834Z"
      }
    ]
  },
  {
    "id": 28891,
    "name": "Numen",
    "slug": "numen",
    "former_names": [
      "Cleancard"
    ],
    "small_logo_thumb_url": "https://bookface-images.s3.amazonaws.com/small_logos/801ff758c035f5849acfdcd35329ec161bd30cef.png",
    "website": "https://www.numen.com",
    "all_locations": "San Francisco, CA, USA",
    "long_description": "",
    "one_liner": "Engineering a future without cancer deaths.",
    "team_size": 18,
    "industry": "Healthcare",
    "subindustry": "Healthcare -> Diagnostics",
    "launched_at": 1691571179,
    "tags": [
      "Machine Learning",
      "Biotech",
      "Healthcare",
      "Diagnostics",
      "AI"
    ],
    "tags_highlighted": [],
    "top_company": false,
    "isHiring": true,
    "nonprofit": false,
    "batch": "Summer 2023",
    "status": "Active",
    "industries": [
      "Healthcare",
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    ],
    "regions": [
      "United States of America",
      "America / Canada",
      "Remote",
      "Partly Remote"
    ],
    "stage": "Growth",
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        "title": "💧🧬Cleancard - Making cancer screening as easy as a pregnancy test",
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        "body": "**Tl;dr:** We’re Cleancard, a pair of Rhodes Scholars on a mission to reinvent cancer diagnostics. We combine synthetic biology + AI to create powerful at-home cancer tests, with results from urine in just 30 minutes. **Check out our **[**website**](https://www.cleancard.bio/)** for more!**\n\nHey everyone - we’re Tom and Luca, the co-founders behind Cleancard!\n\n![uploaded image](/media/?type=post&id=73949&key=user_uploads/863380/9ea23e71-c6d5-4715-8236-7ed89e1d6a90)\n\n👨🏻 [Tom](https://www.linkedin.com/in/thomas-carroll-62a60367/): Clinical cancer researcher, expert in bioinformatics and methods development. No stranger to designing [better biomarker tests](https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00216-7). 👨🏻‍🦰 [Luca](https://www.linkedin.com/in/luca-springer-b3801b8a/): Computer scientist with a strong healthcare policy background. Years of experience growing healthtech and consumer businesses.\n\n### **Early cancer detection saves lives 🕑**\n\nMore than 18M Americans have cancer today. Unfortunately, this is a growth market (26M projected by 2040). 1 in 3 have a close family member with a history of cancer, and thus have a higher risk for cancer themselves (2x). We know these realities all too well from our personal lives, dealing with hereditary cancer syndromes and family histories of cancer.\n\nCancer will come for many of us. To give ourselves drastically better odds of surviving this disease, we need to diagnose it before it reaches an advanced stage.\n\n![uploaded image](/media/?type=post&id=73949&key=user_uploads/863380/10066d6b-22e6-4e98-a5cf-4fc34047d766)\n\n### **Problem: Cancer screening is failing us 🤬**\n\n* Cancer symptoms are often unnoticeable until the cancer is too advanced to cure\n* Current lab-based screening tests are **time-consuming** and **costly** - they fail to get people to screen before they are symptomatic (even for PSA, only [1 in 3 participate](https://jamanetwork.com/journals/jamaoncology/fullarticle/2797845))\n* At-home rapid tests would increase rates of asymptomatic screening but **just don’t perform well enough** to be trusted for cancer diagnostics\n* Current options are **not sufficient** to give people their best chance at surviving cancer\n\n### **Solution: Cleancard’s rapid testing platform 😍**\n\nWe’ve built a new rapid-test method enabling highly sensitive biomarker-guided diagnostics from the urine in just 30 minutes. Key advantages of our proprietary technology:\n\n* **10x quicker/cheaper** than lab-based tests\n* **10x more sensitive** than lateral flow\n* **No expensive machinery** or **complicated sample manipulation**.\n\nSee how we stack up:\n\n![uploaded image](/media/?type=post&id=73949&key=user_uploads/863380/ed2218af-7627-4f5b-9d17-7adec46c6632)\n\nCleancard technology combines synthetic biology, machine learning, and computer vision into a multiplexable, machine-readable format which allows us to detect multiple cancer biomarkers from a single sample.\n\nOur first rapid at-home screens will identify prostate, bladder, and ovarian cancers. Our method is highly agile - we’ve successfully targeted 10 new cancer biomarkers during this YC batch alone, with more to come soon. \n\nCleancard’s platform is the one-stop shop for reliable detection and tracking of multiple cancer biomarkers in the comfort of your own home.\n\n### **Our asks 🙏**\n\n* **Share this post!** Please help us spread the word with your networks.\n* **Join our team!** We are always looking for highly motivated scientists and engineers to join us in our mission to reinvent cancer diagnostics. If that’s you or someone you know, please get in touch ([contact@cleancard.bio](mailto:contact@cleancard.bio)).",
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        "body": "Hi! I’m [Mike](https://linkedin.com/in/polcari), founder of [Haplotype Labs](https://www.haplotypelabs.com). At Haplotype Labs, we believe that more precise prevention and screening will lead to longer healthspan and lower healthcare costs. \n\n![uploaded image](/media/?type=post&id=79664&key=user_uploads/1647013/730b958e-b667-4136-968b-5543aa5b9090)\n\nWe're building the HaploHub: a software platform that helps genetic testing labs, clinical trials, and prevention-focused medical practices to deploy **AI models that use genetics to predict, detect, and prevent disease**.\n\nI joined 23andMe after Series A and helped take it public after over 15 years as VP / Chief Architect. The technology that my team and I developed at 23andMe has delivered more genetic risk reports to more patients than any other in the world, but the translation to patient outcomes remains unsolved. At Haplotype Labs, we are working to close that gap and accelerate the translation of polygenic risk scores into improved healthspan for patients. We’re building the tech I wish I’d had at 23andMe and making it broadly available to the clinic.\n\n**_Precision_ Preventative Care**\n\nPreventative care programs currently stratify patients into risk categories for various conditions based on imperfect but still useful risk factors like demographics and family history. Patient stratification allows a care provider to optimize the financial expense and negative side effects of any given prevention program. For example, people with a family history of colon cancer are typically screened more frequently.\n\nDriven by falling prices of sequencing and improved model power, preventative care is on the cusp of broadly adopting genetic risk models as a means to further personalize these prevention programs and extend healthspan. These models can also play a role in the discovery of new medicines, and can accelerate clinical trials.\n\nPublished methods are improving rapidly and new models are published consistently. However, it is difficult to correctly and reliably compare the performance of these models or deploy them at scale.\n\n**Advanced technology made simple**\n\nWe're building the HaploHub: an easy-to-use SaaS platform for genetic testing labs, concierge medical practices, clinical trials, consumer brands, and payers/providers to:\n\n* predict disease risk for their patients based on proprietary or 4000+ publicly available genetic models using any genome-wide germ-line or methylation assay\n* securely host, manage, and interrogate the genetic data of their population\n* run the most common inference algorithms (phasing, imputation, ibd, etc.) without writing code\n* transition to low-pass sequencing and save 50-90% on sequencing costs\n\n**Get in touch!**\n\nWe’re eager to get this technology out into the world! We would love to speak with concierge practitioners, clinical trial investigators, or anyone interested in using genetics to extend health span. If that sounds like you, please reach out!\n\n[yclaunch@haplotypelabs.com](mailto:yclaunch@haplotypelabs.com)",
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        "full_name": "Abhi Rajendran",
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        "full_name": "Adam Wu",
        "title": "Founder/CTO",
        "founder_bio": "Building the smartest protein engineer in the world.\n\nShameless plug: check out 'adwuu' on spotify for a good time",
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      {
        "id": 92017,
        "title": "Amina: The Agentic Protein Engineer",
        "tagline": "Design, simulate, and test your proteins 100x faster with our no-code platform for protein engineering!",
        "body": "**👋 Hey YC! We're Abhi and Adam from AminoAnalytica.**\n\n**Amina is the first AI agent for end-to-end protein engineering** – instead of wrestling with hundreds of fragmented tools, scientists can now design protein therapeutics through simple conversation.\n\n## **🎬 Trailer**\n\nhttps://www.youtube.com/watch?v=n8Pd9BJcbQA\n\n## **🧬 The Problem with Programmable Biology**\n\nThe 2024 Nobel Prize for Chemistry went to AlphaFold - proving we can predict and design proteins like software. These biological machines could solve climate change, cure diseases, and manufacture anything we need.\n\nBut here's the reality: **hundreds of new computational biology tools launch every week.** Even expert researchers stick to the same old methods they know, missing breakthrough tools that could accelerate their work by months or years.\n\n**Meet Dave, your friendly neighborhood protein engineer** 👨‍🔬\n\nDave is designing a cancer therapeutic, but his current workflow is broken:\n\n* **Inaccessible tools** → most have no UI, require specific hardware, must be built from source\n* **Fragmented ecosystem** → tools don't work together, requiring pages of glue code\n* **Constant obsolescence** → by the time he masters one tool, three better ones have launched\n\nThe result? **Scientists spend more time debugging code than designing life-saving therapeutics.**\n\n## **🚀 Our Solution**\n\n**What if you could just describe what you want in plain English?**\n\nInstead of wrestling with complex pipelines and staying up-to-date with every new tool, you simply tell Amina what protein you need and why.\n\n**Dave before Amina:**\n\n![uploaded image](/media/?type=post&id=92017&key=user_uploads/1754946/ad201bdd-6ed8-4b33-bb1f-fd8ca58f5262)\n\n**Dave with Amina:**\n\n![uploaded image](/media/?type=post&id=92017&key=user_uploads/1754946/3657d135-74af-4ed9-b261-394f14fe42a5)\n\n## **🔬 What Makes Amina Different**\n\nThis isn't just model hosting. Amina is trained on both scientific literature and our proprietary experience from engineering thousands of proteins for customers - it knows which tools to use when, how to chain them together, and how to interpret results. It's like having our entire computational team's expertise distilled into a single agent.\n\nWith our no-code interface, 50+ specialized tools work together seamlessly. Amina catches potential issues, suggests optimizations, and explains results in plain English.\n\n## **🎯 Our Vision**\n\n**Our ultimate goal is for Amina to design proteins autonomously** - think JARVIS, but dedicated to discovering breakthrough therapeutics. For now, it's like having an extra bioinformatician on your team that needs less care and attention than your cell cultures.\n\n## **🙏 Our Ask**\n\n**If you work in biotech, pharma, or have an interest in protein engineering** - we'd love your feedback on Amina.\n\n**Try it for free at [aminoanalytica.com](http://aminoanalytica.com)** - no setup required, start designing in 60 seconds.\n\nNeed extra credits? Just message us at [support@aminoanalytica.com](mailto:support@aminoanalytica.com)",
        "url": "https://www.ycombinator.com/launches/Nw9-amina-the-agentic-protein-engineer",
        "votes": 15,
        "created_at": "2025-07-09T18:31:25.117Z"
      },
      {
        "id": 82706,
        "title": "🧬 AminoAnalytica – Next generation proteins engineered with *protein* language models",
        "tagline": "We’re creating the next generation of peptides and enzymes using our proprietary pipeline, powered by protein language models.",
        "body": "Hey everyone – it’s [Abhi Rajendran](https://www.linkedin.com/in/abhirajen/), [Adam Wu](https://www.linkedin.com/in/akhwu/) and [Matteo Peluso](https://www.linkedin.com/in/matteo-peluso-872b85199/)\n\n**Tl;dr**: just look at the pictures ;)\n\n# **💞 The A(mino) Team**\n\n![uploaded image](/media/?type=post&id=82706&key=user_uploads/1754946/96f298df-f236-4401-91d5-2ce61024e644)\n\n👨🏾 **Abhi Rajendran** – From Imperial College London to the Mercedes F1 Team, Abhi builds AI tools in data-intensive environments. AminoAnalytica was inspired by his computational bio master’s project and was the top AI x Robotics venture from Imperial in 2024.\n\n👦🏻 **Adam Wu** – With experience in academic and industry wet labs, Adam is now building his own. He has a background in materials science, tissue engineering and biosensing as a Thermo Fisher Scholar from Imperial.\n\n👱🏼‍♂️ **Matteo Peluso** – Bioinformatics PhD from the University of Zurich. His skills in biology, machine learning, and software development tie up everything seamlessly.\n\n👨🏻‍🦱 **Dr. Stefano Angioletti-Uberti** – Senior lecturer at Imperial, specializing in modeling biological and soft matter systems. He ensures models are based on the latest scientific principles.\n\n# **❌ Problem: better proteins are needed to accelerate global innovation**\n\n* Industrial and pharma companies prefer to use enzymes and peptides over harsh chemicals as they are more specific and sustainable.\n* However, natural proteins often lack stability, efficiency, or specificity for their desired applications leading to poor performance\n* Improving these proteins has been a costly and inefficient 'trial-and-error' process, where biotech companies randomly mutate existing proteins, test them, and repeat until success.\n\n![uploaded image](/media/?type=post&id=82706&key=user_uploads/1754946/afb4dbcf-6cc7-43e1-915e-609278e798fa)\n\n# **✅ Solution: AminoAnalytica’s protein adaptation platform, powered by PLMs**\n\n* Like how ChatGPT understands human language, our **\"protein language models\" (PLMs)** understand biology and can optimize proteins for industrial and therapeutic use.\n* This allows us to perform in-silico protein property prediction, eliminating the need for thousands of lab tests.\n* We’re transforming the traditional ‘trial-and-error’ method into an ultra-high throughput and rational process.\n\n![uploaded image](/media/?type=post&id=82706&key=user_uploads/1754946/65fb8e1a-d749-4245-adca-a0abc1ad8529)\n\n# **🤝 Any industry working with proteins can benefit from our tech**\n\nCurrently, we’re working on:\n\n* **Aquaculture feed** → enzymes for maximizing fish feed nutritional efficiency\n* **Pharmaceuticals** → peptide drugs with improved stability and specificity\n* **Climate tech** → enzymes for eco-friendly carbon capture\n* **Consumer goods** → safer enzymes for everyday products\n\n![uploaded image](/media/?type=post&id=82706&key=user_uploads/1754946/30bf87a9-4ee8-49e6-a0ee-7f8dd85bf008)\n\n# **🐡 Get in touch with us!**\n\n* Upvote/share this post with your network and help spread the word!\n* If you (or anyone in your network) are as excited as we are about next generation industrial proteins and would like to learn more about what we’re doing, email us here - [founders@aminoanalytica.app](mailto:founders@aminoanalytica.app)\n* We’re also looking to expand **our advisory board** in the areas of aquaculture, fish testing, and feed manufacturing!\n\n![uploaded image](/media/?type=post&id=82706&key=user_uploads/1754946/908a3520-d234-4338-ad05-154aa3515672)\n\n",
        "url": "https://www.ycombinator.com/launches/LVy-aminoanalytica-next-generation-proteins-engineered-with-protein-language-models",
        "votes": 138,
        "created_at": "2024-08-04T00:01:55.931Z"
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    "id": 31434,
    "name": "Adialante",
    "slug": "adialante",
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    "all_locations": "San Francisco, CA, USA",
    "long_description": "We know how to improve cancer outcomes by 8x-10x: you catch it early. \r\n\r\nMRI is the most robust and powerful cancer-detection tool in the world, yet systems cost millions to purchase, take months to install, and require high levels of technical skill to operate. We've redesigned MRI from the ground up with new physics, algorithms, and hardware, all to bring cancer screening to the entire world. \r\n\r\nOur mobile MRI is an imaging clinic on wheels. No equipment to buy, no infrastructure needed. For a flat per-scan fee, any medical site can offer MRI cancer screening. Starting with prostate cancer. Then everything else.",
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    "batch": "Spring 2026",
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    "primary_partner": {
      "name": "Nicolas Dessaigne",
      "url": "https://www.ycombinator.com/people/nicolas-dessaigne"
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    "founders": [
      {
        "user_id": 1230366,
        "full_name": "Efrain Torres",
        "title": "Founder/CEO",
        "founder_bio": "CEO, making MRI a mass market cancer screening tool. ",
        "is_active": true,
        "linkedin_url": "https://www.linkedin.com/in/dr-efra%C3%ADn-torres-85293512a/",
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        "full_name": "Parker Jenkins",
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        "founder_bio": "COO at Adialante. Making cancer screening affordable. ",
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        "linkedin_url": "https://www.linkedin.com/in/parker-jenkins-486893130/",
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        "id": 98651,
        "title": "Electrical Engineer",
        "url": "https://www.ycombinator.com/companies/adialante/jobs/UMcHMIR-electrical-engineer",
        "location": "Menlo Park, CA, US",
        "type": "Full-time",
        "role": "Engineering",
        "role_type": "Electrical",
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        "experience": "Any (new grads ok)",
        "visa": "Will sponsor",
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        "url": "https://www.ycombinator.com/companies/adialante/jobs/XczOeQ5-senior-quality-engineer",
        "location": "Menlo Park, CA, US",
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        "url": "https://www.ycombinator.com/companies/adialante/jobs/OyWyAGn-mri-tech",
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        "type": "Contract",
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    "launches": [
      {
        "id": 101289,
        "title": "Adialante: We're going to screen the world for cancer!",
        "tagline": "Our second patent just issued, a new way to make MRI.",
        "body": "**TLDR**: Adialante builds compact and mobile whole-body MRIs. We already have $12.75M in LOIs, $30k in deposits, and our first system will be scanning by demo day.\n\n---\n\n##### **About Us:**\n\n<https://youtu.be/iiRwpHPFIeM>\\\n\\\n\"Disruptive Innovation describes a process by which a product or service takes root in simple applications at the bottom of the market — typically by being less expensive and more accessible — and then relentlessly moves upmarket, eventually displacing established competitors.\" — Christensen Institute\n\nWe’re [@Efrain Torres](https://bookface.ycombinator.com/user/1230366) and [@Parker Jenkins](https://bookface.ycombinator.com/user/1298954), the co-founders of [@Adialante](https://bookface.ycombinator.com/company/31434). We met on the first floor of our engineering dorm. And when we learned what disruptive innovation was, it captured us immediately. But what to disrupt? Trained as biomedical engineers, we both learned about MRI and were in awe of the clinical value. It can diagnose cancers, strokes, dementia, and more. Yet everyone said the same thing: MRI is not accessible.\n\nSo we knew what we had to do: disrupt the industry.\n\nOver the past six years, we've invented new ways to do MRI, won millions in competitive grants, published research, secured patents (#12,625,209, #12,372,595, more to come), and built a team. And, now, we’re well on our way to disrupting the industry.\n\n##### **Problem:**\n\nWe know how to 10x cancer outcomes: **you catch it early**. MRI is the most powerful cancer-detection tool in the world, yet systems cost millions to purchase, take months to install, and require high levels of technical skill. The result? We only use MRI when it's too late.\n\n##### **Our solution:**\n\nWe've redesigned MRI from the ground up with new physics, algorithms, and hardware, all to bring cancer screening to all of us. Our MRIs:\n\n* use 50% less hardware\n* are 40% shorter and 80% lighter\n* are whisper-quiet and much less claustrophobic\n* and require no specialized infrastructure\n\nAll while maintaining the diagnostic quality patients need.\n\n![uploaded image](/media/?type=post&id=101289&key=user_uploads/1230366/e7c9bf11-8868-457b-aced-78bd369559f5)\n\nBut like Waymo, we won't sell our hardware — we'll own and operate it. We'll bring our MRIs to clinics in mobile trailers, handle its operations, and continuously improve our AI software after every scan. We're an imaging clinic on wheels. So instead of a clinic waiting months and paying millions, clinics will wait hours and pay hundreds.\n\n![uploaded image](/media/?type=post&id=101289&key=user_uploads/1230366/31ce218b-56df-4fc3-9450-5af5eea83895)\n\n---\n\nWe're starting with prostate cancer. **Over 1M men every year require an MRI before a prostate biopsy, but virtually none of the urology clinics that treat them can offer one.**\n\nAfter our per-scan fee, a clinic will collect the insurance reimbursement and make a profit. It's a win-win-win: we get the recurring revenue, they get a new revenue stream, and patients get the best imaging technology in the world. From there, the same piece of hardware expands to renal, breast, and brain scanning **until annual screening for high-risk cancers is the norm, not the exception.**\n\n**Traction:**\n\n* 6 clinics signed up\n* $12.75M in LOIs for scanner utilization\n* $30k deposited from a top ten urology clinic to reserve their spot in line\n* MRI assembled\n\n  ![uploaded image](/media/?type=post&id=101289&key=user_uploads/1230366/1fa5afed-cb5b-4f8d-a3f0-46a430043c0e)\n\n\n##### **Asks:**\n\nIntros to Urology clinics\n\n##### **Open Invitation:**\n\nWant to see our scanner? Shoot us a message! We’ll show you our system in person!",
        "url": "https://www.ycombinator.com/launches/QLh-adialante-we-re-going-to-screen-the-world-for-cancer",
        "votes": 31,
        "created_at": "2026-05-13T18:24:48.396Z"
      }
    ]
  }
]
