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        "full_name": "Dimitris Fotis Sakellariou",
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        "title": "Research Engineer - Foundational AI",
        "url": "https://www.ycombinator.com/companies/piramidal/jobs/neQ9JaN-research-engineer-foundational-ai",
        "location": "New York, NY, US / London, England, GB",
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        "role": "Engineering",
        "role_type": "Machine learning",
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        "equity_range": "",
        "experience": "3+ years",
        "visa": "US citizen/visa only",
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        "title": "Front End Engineer - User Interface",
        "url": "https://www.ycombinator.com/companies/piramidal/jobs/EBwEaGc-front-end-engineer-user-interface",
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        "equity_range": "0.40%",
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        "experience": "6+ years",
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        "title": "Piramidal's foundation model for brain waves could supercharge EEGs | TechCrunch",
        "url": "https://techcrunch.com/2024/08/23/piramidals-foundation-model-for-brainwaves-could-supercharge-eegs/",
        "date": "Aug 23, 2024"
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        "id": 78840,
        "title": "Piramidal: Foundation model for the brain 🧠",
        "tagline": "Get instant diagnosis for the vast majority of neurological conditions using our Foundational AI.",
        "body": "### **What is a brain foundation model?**\n\nWe are building a foundation model, from the ground up, trained on a massive and diverse corpus of brainwave data i.e. Electroencephalography (EEG). In other words, similar to how Large Language Models (LLM) are trained on human language ie. text, our model is trained on brain language ie. brainwaves. \n\nOur foundation model will be able to understand and detect the many facets of brain activity, from disease to wellbeing. Crucially, **similar to how ChatGPT can be fine-tuned to become a lawyer or a python developer, our brain foundation model will easily be fine-tuned to become a neurologist co-pilot or a biomarker discovery assistant.** And, this is only our first milestone - more on this below.\n\n![uploaded image](/media/?type=post&id=78840&key=user_uploads/1662387/900c449d-eefe-4a06-a12b-60617c60c437)\n\n### **The opportunity**\n\nOur brain foundation model will address a variety of use cases with minimal training, such as:\n\n* **Diagnosis** of a vast majority of neurological conditions.\n* Drug and **biomarker discovery** in clinical trials. \n* **Remote monitoring** of brainwave abnormalities, e.g., treatment response to drugs or sleep irregularities.\n* Real-time tracking of brain health, such as cognition or head injuries, measured through **helmets in sports and military**.\n* Empowering devices such as **Apple Vision Pro and Meta Quest** to translate brain signals into everyday actions.\n\n### **Why are we starting with neurological conditions?**\n\nDuring his PhD at London's St Thomas' EEG department, Dimitris discovered a key insight: EEG is a crucial test for neurological disorders, but its manual review process is both slow and error-prone. Specifically:\n\n* **Neurologists manually inspect the EEG** brainwaves to identify abnormal patterns. This can lead to a 30% margin of error and crucially misdiagnoses.\n* There is a **substantial rise of EEG data** being collected, due to the deployment of  remote EEG devices. Despite these remote devices continuously recording patients at home, there is no way to review this enormous and continuous stream of incoming data. \n* Conversely to the upward EEG data trend, **there is an extreme shortage of neurologists** leading to wait times lasting several months.\n\n### **Our first product**\n\nOur first product is **a copilot for epilepsy diagnosis**. The product, which is powered by our brain foundation model, will assist neurologists by obtaining diagnostic insights around a patient’s EEG, in real time. This approach cuts down the time to review EEG from hours to seconds. Additionally, our standardized EEG analysis reduces the margin of error from manual inspection, which in many cases leads to misdiagnosis and recurrent hospital visits.\n\nShortly after epilepsy, we will fine tune our foundation model to provide diagnosis for a vast majority of other conditions such as sleep and cognitive disorders.\n\n### **Who we are**\n\nWe are [Dimitris](https://www.linkedin.com/in/sacellarius/) and [Kris](https://www.linkedin.com/in/kris-pahuja-a59a905b/). Dimitris has a **PhD in neuroscience and AI**, and has been working on EEG for 12 years, but also shipped production level AI as a deep learning lead at IQVIA. Kris has a product background, building **healthcare and AI products across Google and Spotify**. We are both avid musicians and love punk rock. \n\n### **Our ask..**\n\nWe are looking for intros to:\n\n1. Neurologists, sleep doctors, neurotech companies, or companies in clinical trials in order to sign LOIs. We can automate the analysis of the brainwave (EEG) data at a fraction of their current cost.\n2. Academic or healthcare institutions that store EEG data. In exchange for accessing their EEG records, we will provide our model for free for research purposes.\n\nYou can send them our way to [info@piramidal.ai](mailto:info@piramidal.ai)!\n\nPlease also share our post and spread the world - you never know who it might help! 🖤",
        "url": "https://www.ycombinator.com/launches/KVc-piramidal-foundation-model-for-the-brain",
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        "created_at": "2024-02-28T04:10:49.070Z"
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    "long_description": "We use AI and high-throughput mouse studies to discover therapeutics that modify neural activity in the brain. The initial focus is on epilepsies associated with autism and Parkinson’s disease with the potential to expand to any neurological disorder underlined by a dysfunction in neural activity. Our R&D is guided by AI models trained on high-density multimodal mouse data generated in-house.\r\n\r\nWe are 3 Oxford-trained neuroscientists supported by an experienced SAB from Harvard, Science Corp (ex-Neuralink), EPFL, Meta, and UCL.\r\n\r\nIn 1.5 months since landing in SF, we went from nothing to (1) opening and operating an animal lab in South SF, (2) obtaining a proof-of-concept in mice, (3) building a multimodal AI model that directs our screening approach and (4) submitting two provisional patents; all while utilizing less than 50% of our YC funding. \r\n",
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        "full_name": "Gabriel Ocana Santero",
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        "id": 86986,
        "title": "Exin Therapeutics: An AI discovery platform for neurotherapeutics",
        "tagline": "Precise modulation of neural activity across neurological disorders.",
        "body": "[Exin Therapeutics](https://www.exintherapeutics.com/) uses AI and high-throughput mouse studies to develop therapies for people suffering from neurological and neuropsychiatric disorders. We are tackling conditions like epilepsy, debilitating symptoms of autism spectrum disorder (ASD), and Parkinson’s disease by focusing on the neural circuitry of the brain.\n\n# **Why is this important?**\n\nMillions of people around the world suffer from neurological disorders. These disorders arise from imbalances in brain activity. Think of it like an orchestra where some instruments are playing too loud while others are too quiet. This “bad music” / neural imbalance—what we call excitatory/inhibitory (E/I) imbalance—is the root cause of many symptoms in these disorders. For example, in epilepsy, overactive circuits lead to seizures, while in ASD, it can cause sensory hypersensitivities - where individuals feel overwhelmed by normal sounds, lights, or touch that most people wouldn't even notice. These dysregulations in neural circuits impact how the brain processes information and responds to the world, leading to the debilitating symptoms we see in these disorders.\n\n# **Our solution**\n\nWe’re taking a circuit-level approach to treating brain disorders. Instead of trying to restore missing genes, we’re supplementing already existing genes that we know will be directly changing the neural activity in the brain - in the direction that we want and independently of the genetic background.\n\n![uploaded image](/media/?type=post&id=86986&key=user_uploads/89898/4181e602-6279-4611-9af3-73b0ccfca768)\n\nWe are also working on a multimodal AI model to streamline our preclinical R&D. Why? Well, because developing drugs for the brain is really tough. Every candidate needs to be tested for its ability to modulate circuits, and doing that through a traditional drug development preclinical pathway is a slow process.\\\n\\\nBecause of that, we use ML to analyze high-density multimodal data sets and prioritize which drugs are worth testing further. We use neural activity, behavior, and transcriptomics to train multimodal AI models that identify the drivers of the disease not observable by conventional analytical methods.\n\n![uploaded image](/media/?type=post&id=86986&key=user_uploads/89898/b1ad1c24-a513-4633-83f6-58378d1cb5d8)\n\nThen, we use these models to (1) predict the potential of our therapies to treat particular indications and (2) provide an efficacy readout during our internal experimental testing. This way, we spend our time (and funding) testing the most promising candidates.\n\n# **Our ask**\n\n1. Intros: If you have contacts in pharma, working on complementary tech, or have ideas for partnerships, we’d love to connect.\n2. We'd love to hear from people who have worked in therapeutics and people with IND-enabling programs or clinical trial design experience.\n\n# **Team**\n\nWe are a team of 3 Oxford-educated neuroscientists. [Gabriel](https://www.linkedin.com/in/gabriel-ocana-santero-85b41819a/?originalSubdomain=uk) is a biochemist with a wealth of research experience in neural development, gene therapy, and NeuroAI. He holds a PhD in Pharmacology from Oxford. [Ivan](https://www.linkedin.com/in/ilazarte/) is a physicist by training and has worked in molecular biology, circuit, and systems neuroscience. Ivan’s brother suffers from ASD and Ivan is on a mission to improve the quality of life for patients suffering from debilitating neurological conditions. He holds a PhD in neuroscience from Oxford. [Marko](https://www.linkedin.com/in/marko-tvrdic/?originalSubdomain=uk) has experience with iPSC models, retinal disorders, and circadian and developmental neuroscience. During his PhD, he worked in systems and behavioral neuroscience and holds an MSc from Oxford.\n\n![uploaded image](/media/?type=post&id=86986&key=user_uploads/1960211/5487d1f0-6cbc-4728-af74-a8377516e2d3)\n\nWe are supported by a team of advisors from top industry and academic institutions - including Harvard & UCL.",
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        "created_at": "2025-01-20T22:29:09.667Z"
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        "full_name": "Sean Cole",
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        "id": 109992,
        "title": "Parasma: Training human brain cells for compute",
        "tagline": "In March, we trained them to play Doom; now we got them to do next-token prediction.",
        "body": "We train human brain cells for compute. In March, we trained them to play Doom; now we got them to do next-token prediction.\n\n![uploaded image](/media/?type=post&id=109992&key=user_uploads/3388159/cbefdb79-ad5b-4e03-ae35-d2a482a05351)\n\n![uploaded image](/media/?type=post&id=109992&key=user_uploads/3388159/ce53a90f-7180-4eab-b23e-d770a5e375a7)\n\n**The Problem**\n\nModern models require enormous amounts of energy and training data, while still struggling with continual learning and adapting efficiently to new tasks. Biological brains solve these problems very differently. They learn continuously, adapt from limited experience, and operate on roughly the power of a light bulb.\\\n\\\n**Solution**\n\nParasma is developing the algorithms and infrastructure needed to turn human brain cells into useful compute. The human brain is the most capable and energy-efficient learning system we know. Our goal is to reliably train biological substrates and use them for general computation, robotics, and eventually direct biological training. In March, we trained human brain cells to play Doom, which got hundreds of millions of views across social media. Since then, we’ve been working toward more general tasks. Most recently, we got the cells to perform token prediction: given a sequence of tokens converted to electrical stimuli, the neurons learn to predict what comes next with no GPU.\n\nLong-term, biological compute will offer orders-of-magnitude improvements in energy and sample efficiency, while enabling native continual learning.\n\n**Team**\n\nI previously worked on neuromorphic computing and reinforcement learning during my master’s.\n\nBefore that, I built a successful digital-item marketplace with > $1.7M of listed goods and played games professionally.\\\n\\\nCheck out our press release here:\\\n<https://parasma.com/news/human-brain-cells-do-next-token-prediction>",
        "url": "https://www.ycombinator.com/launches/Sc4-parasma-training-human-brain-cells-for-compute",
        "votes": 10,
        "created_at": "2026-08-13T20:30:00.164Z"
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    "website": "https://dydema.com/",
    "all_locations": "San Francisco, CA, USA",
    "long_description": "We’re building a brain-computer interface anyone can wear, so you can use a computer at the speed of thought. To get there, we’re recording brain data at model company scale.",
    "one_liner": "A consumer brain-computer interface you can map to anything.",
    "team_size": 2,
    "industry": "Consumer",
    "subindustry": "Consumer",
    "launched_at": 1790760468,
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